Finally, you can give Kayexalate and furosemide to dispose of the excess potassium.
Urine potassium levels can help determine the etiology of the hyperkalemia.
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Bladder neck: Anticholinergics, tumor.
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PTHrP secretion from cancer cells (often squamous cell carcinoma) can cause a paraneoplastic hypercalcemia.
Patients can present in fluid overload from urinary retention.
Acute interstitial nephritis yields a UA with eosinophils, WBCs, and WBC casts.
Postrenal failure: Caused by urinary outflow obstructions in one or both ureters, the bladder neck, the urethra, or the prostate.
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D5W, or oral water depending on the patient's volume status.
Given this patient's worsening cough, you might also consider a CXR, as this may be relevant in the setting of SIADH.
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The kidneys are unresponsive to ADH.
What are the next steps in diagnosis?
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Causes include excessive hydration with hypertonic fluids, dysfunction of central regulation, and mineralocorticoid excess (consider if the patient has hypokalemia and hypertension).
Check calcium, phosphate, albumin, ionized calcium, and alkaline phosphatase.
If the patient has a large postvoid residual, he should keep his Foley in place and be referred to urology.
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Causes of Acute Renal Failure.
Start by administering calcium to stabilize the heart.
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Acidosis with nephrolithiasis suggests uric acid or cystine stones.
Note that overly rapid correction may result in central pontine myelinolysis (flaccid paralysis, dysarthria, dysphagia, and gait abnormalities).
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Examination should include checking BP, daily weights, and assessment of volume status.
ATN, acute interstitial nephritis, vasculitis, or anything causing renal ischemia.
Order a repeat blood draw unless suspicion is high.
GI absorption (as found in hypoparathyroidism, pseudohypoparathyroidism, vitamin D deficiency, malabsorption, renal failure, critically ill patients, and hypomagnesemia), acute pancreatitis, rhabdomyolysis, tumor lysis, and diuretics.
Usually indicates that the kidneys are wasting potassium.
CHF before giving the bolus!
Evaluate the patient for urinary retention, as this is likely the cause of his renal failure.
Consider in patients with pancreatitis, refractory peptic ulcer disease, a personal or family history of kidney stones, or bone pain.
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To ensure the patient's safety, order an ECG (may show a short QT interval).
Do not give patients with SIADH NS, as this can paradoxically worsen the hyponatremia.
Hemodialysis is a last resort.
You call the laboratory, and they state that the specimen was not hemolyzed.
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What should you do next?
Check plasma and urine osmolalities and sodium.
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Other findings are specific to the etiology of the renal failure.
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When serum sodium is low or rapidly decreasing, hyponatremia may lead to cerebral edema that may result in seizures, status epilepticus, coma, or even death.
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Intrinsic failure: Can be vascular, glomerular, tubular (most common), or interstitial.
Uosm should not respond to DDAVP challenge.
May present with fatigue, muscle weakness or cramps, ileus, hyporeflexia, paresthesias, and flaccid paralysis if severe.
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Pyelonephritis or interstitial nephritis.
Get an ECG, as this may show serious signs of hyperkalemia.
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Often asymptomatic, but may present with confusion, lethargy, muscle cramps, and nausea.
Posm ratio to help determine the cause.
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Severe or symptomatic hyperkalemia, hyperkalemia refractory to the above management, or patients on chronic hemodialysis may require acute hemodialysis.
Restrict dietary potassium and discontinue any medications that may be contributing to the hyperkalemia.
What do you do next?
You may be able to bump hyponatremia to the bottom of your problem list, but central pontine myelinolysis will go to spot number one!
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Consider ordering a CXR.
The pituitary does not make ADH.
WBCs is always abnormal except when the sample is contaminated (eg, with epithelial cells).
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The man has a past medical history of smoking and CAD.
Tx: Replace with calcium carbonate orally or with IV calcium gluconate.
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Identify and treat the underlying cause.
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Alkalosis is most commonly associated with Proteus UTIs but may also be seen with some strains of Klebsiella, Pseudomonas, Providencia, and Staphylococcus.
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Effects of hyperkalemia as seen on ECG.
Usually indicates a nonrenal source of hypokalemia.
Next, follow the mnemonic C BIG K Drop.
Euvolemic hyponatremia: If the patient is symptomatic, give hypertonic NS with furosemide.
ARF but should prompt one to test for it.
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DM, is in the hospital receiving IV antibiotics for pyelonephritis.
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Also consider vitamin D levels, SPEP, TSH, and imaging.